Review the latest information on the efficacy and safety of fixed-dose LAMA/LABA combinations in treatment of patients with COPD, as presented at a recent meeting in San Francisco. Ask our experts your questions related to COPD and find answers to questions from the meeting.
An Update on Fixed-Dose LAMA/LABA Inhalers in COPD
Long-acting bronchodilators are the cornerstone of maintenance therapy for patients with chronic obstructive pulmonary disease (COPD). A variety of long-acting muscarinic antagonists (LAMA) and long-acting β2-agonists (LABAs) are available for the management of COPD. An increasing number of fixed-dose LAMA/LABA combinations have been developed and approved; these combinations have the potential to provide synergistic effects through different mechanisms of action, maximize bronchodilation, and simplify COPD treatment regimens. Authored by Richard Casaburi, MD, Gary Ferguson, MD, and David Mannino, MD, this supplement provides a review of the safety and efficacy of current and emerging inhaled fixed-dose LAMA/LABA combinations for patients with COPD.
Do you Have a Question for a COPD Expert?
FAQ is an opportunity for you to have your COPD clinical questions addressed by expert faculty. Your questions will be answered by email within 2 weeks.
Does the FLAME data put indacaterol/glycopyrrolate as a superior LABA/LAMA in the ex US scenario based on existing evidence to date?
Does GFR influence your choice of LAMAs?
Re the WISDOM trial post-hoc analyses -- Do you routinely use eosinophil counts prior to stepping off ICS/LABAs?
For GOLD A and B patients, when do you use LABAs first versus LAMAs first? Do you use lung volumes and spirometry, and if the patient is hyper-inflated, do you use a LAMA first?
Is there a biologic rationale for not using off-label inhaled steroids plus LABA/LAMA combination when stepping up?
Fixed Dose LAMA/LABA Inhalers in COPD: What the Trials Tell Us
These slides are from a recent symposium held in San Francisco on May 17, 2016. Through an interactive, case-based format, Dr. Richard Casaburi, Dr. Gary Ferguson, and Dr. David Mannino present an overview of the efficacy and safety of current and emerging fixed dose LAMA/LABA combination inhalers for patients with COPD.
Click here to download the COPD Foundation's provider and patient resource sheet